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Thursday, August 31st, 2017

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    9:59a
    Neighboring exoplanets may hold water, study finds

    Seven Earth-sized exoplanets circle the ultracool dwarf star TRAPPIST-1, just 40 light-years from our own blue planet. Now an international team of scientists at the Geneva Observatory in Switzerland, MIT, and elsewhere, report that the outer planets in this system may still hold significant stores of water. Three of these potential water worlds are also considered within the habitable zone of the star, giving further support to the possibility that these neighboring planets may, in fact, be hospitable to life.

    The team’s results, published today in The Astronomical Journal, are based on observations of the TRAPPIST-1 star made by the NASA/ESA Hubble Space Telescope. The researchers trained the telescope on the star to measure its current ultraviolet radiation, and used these measurements to estimate how the star’s energy changed over the course of billions of years. They then modeled how the star’s energy may have affected the water resources on each of the TRAPPIST-1 exoplanets over the last 8 billion years.   

    Scientists’ current knowledge of the system suggests that these planets originally formed much farther out from their star, in a cold zone populated with crystals of water ice, which the planets likely captured as they came together, potentially creating tremendous stores of water, both in the planets’ interiors and on their surfaces.

    From their observations and modeling, the researchers conclude that, over the past 8 billion years, heat and radiation from the star may have caused the innermost planets to lose more than 20 times the amount of water in all of Earth’s oceans. Meanwhile, they say, the outer planets would have lost much less, suggesting they could still retain some water on their surfaces and in their interiors.

    “In terms of habitability, this is a positive step forward to say that hopes are still high,” says study co-author Julien de Wit, a postdoc in MIT’s Department of Earth, Atmospheric and Planetary Sciences. “This concludes that a few of these outer planets could have been able to hold onto some water, if they accumulated enough during their formation. But we need to gather more information and actually see a hint of water, which we haven’t found yet.”

    A water vapor break-up

    In February of 2016, de Wit and others from the University of Liege in Belgium announced the discovery of the seven Earth-sized planets around TRAPPIST-1. The discovery marked the largest number of Earth-sized planets discovered in a single system.

    Since then, de Wit, lead author Vincent Bourrier of the Geneva Observatory,

    and an international team of researchers used the Hubble Space Telescope Imaging Spectrograph (STIS) to measure the amount of ultraviolet radiation given off by the TRAPPIST-1 star then received by its planets. If a planet’s atmosphere harbors water vapor, the presence of ultraviolet radiation can act to break up that water vapor, into oxygen and hydrogen — a process that occurs today on Earth. As oxygen is heavier than hydrogen, it sinks towards the surface, while hydrogen rises through the upper atmosphere.

    The researchers hoped that by using Hubble’s imaging spectrograph, they might look for signs of hydrogen, particularly around two of the middle planets. The researchers were focused on a very narrow region of the ultraviolet spectrum, called the Lyman-alpha band, which is sensitive to hydrogen. They reasoned that if they picked up traces of hydrogen around either planet, that would suggest the presence of water vapor.

    In 2016, the team trained the telescope on the TRAPPIST-1 system over one observing run of five orbits for each planet, totaling eight hours, in which they gathered 4.5 hours of data. Unfortunately, the observations of whether each planet contained hydrogen, and therefore water vapor, were inconclusive.

    However, the researchers also obtained measurements of the star’s ultraviolet flux, or the strength of its radiation. They compared these measurements to similar ones made the previous year.

    “We see this flux is actually changing, and we can use this change to backtrack and have an understanding of how much energy the star is putting on each planet over the course of the planets’ lives,” de Wit explains.

    Oceans lost

    Based on previous estimates of the planets’ densities, the scientists assume that the planets likely formed much farther out from their current positions, beyond what is considered the “ice line” — the distance from the star, beyond which space is cold enough for ice crystals to spontaneously form. It’s likely that all seven TRAPPIST-1 planets took shape within this zone, taking up significant volumes of water ice as they formed.

    Researchers have also previously observed that the planets’ orbital configurations are such that they likely migrated together, “moving as a pack,” as de Wit describes, eventually taking up their current positions, closer into their star. As they migrated into the star’s warmer zone, the star’s ultraviolet radiation likely started to strip away and evaporate the planets’ water resources.

    In their current paper, the scientists used their estimates of the star’s ultraviolet flux over the last 8 billion years to estimate the amount of water the the planets likely lost as they migrated over this period of time, closer in to their star.

    The team plugged the estimates of ultraviolet flux into two separate models: an atmospheric model that calculates the amount of water vapor that might be lost given a certain ultraviolet concentration, and a geophysical model that estimates how much water ice and other volatiles, buried deep in a planet’s interior, can be brought back up into the atmosphere via outgassing.

    From their modeling, the scientists estimate that the innermost planets lost more than 20 times Earth’s current oceanic water stores over their 8-billion-year journey toward their star, while the outermost planets lost much less, equivalent to around three times the ocean stores on Earth.

    “Earth-sized planets can capture hundreds of Earth-oceans’ worth of water when they form, but it’s highly dependent on so many factors, and difficult to say,” de Wit says. “We can say the inner ones probably lost a huge amount of water, and the outer ones way less, allowing them to actually still have some water, if they captured it when they first formed.”

    “It depends a lot on their initial water content,” Bourrier adds. “If they formed as ocean planets, even the inner ones would likely still harbor a lot of water. We are still a long way to determining the habitability of these planets, but our results suggest that the outer ones might be the best targets to focus our future observations.”

    De Wit and his colleagues are planning another observing run, and will use Hubble to monitor the system more closely, spending more time observing, and trying to look for clouds of hydrogen around each planet as they transit, or cross in front of their star.

    “If the planet’s atmosphere holds water vapor, and it is losing hydrogen as it reacts with ultraviolet radiation, it will look a bit like a gigantic comet with a tail, or a sphere that’s 10 times bigger than the planet, filled with atomic hydrogen, that is slowly flowing out of the planet, forming a tail from the stellar wind,” de Wit says. “It’s amazing how quickly our perspective on this [system] has changed. It’s really a steep learning curve that is really exciting.”

    This research was supported, in part, by NASA, the Space Science Telescope Institute, the Swiss National Science Foundation, the Simons Foundation, the Belgian National Fund for Scientific Research, and the Gruber Foundation.

    12:00p
    New way to test antibiotics could lead to better drugs

    MIT and Harvard University researchers have engineered E. coli cells that can be used to study how bacteria at an infection site respond to antibiotic treatment, allowing scientists to learn more about how existing antibiotics work and potentially help them to develop new drugs.

    In the new study, which appears in the Aug. 31 issue of Cell Host and Microbe, the researchers found evidence that some existing hypotheses about how bacteria respond to antibiotics are not correct.

    “Our study shows that using engineered organisms can give you a window into infection sites and expand our understanding of what antibiotics are actually doing. This work indicates that some of our assumptions may be wrong,” says James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering and the senior author of the study.

    The paper’s lead author is Laura Certain, a clinical fellow at Harvard’s Wyss Institute for Biologically Inspired Engineering.

    Engineering bacteria

    Much of the research in Collins’ lab focuses on trying to understand how antibiotics work, in hopes of designing more effective drugs. For the new study, Collins wanted to apply synthetic biology — the construction of novel genetic circuits in living cells — to design bacteria that could be used to study antibiotics and infection.

    Most studies of how antibiotics work are done with bacterial cells grown in a lab dish. However, Collins and Certain suspected that these drugs’ effects could be different in living animals because that environment, including available nutrients and other conditions, is very different from a lab dish.

    To allow them to study antibiotics under more realistic conditions, the researchers engineered a strain of E. coli bacteria that expresses a genetic “toggle switch” that flips only under certain conditions. Such switches can be incorporated into bacteria to allow them to record events such as exposure to a chemical.

    In this case, the researchers designed the bacteria to reveal whether they were dividing or not, allowing them to explore how antibiotics affect cells in either state. Previous studies done in bacteria grown in a lab dish have found that most antibiotics work better on cells that are dividing, while non-replicating cells are much harder to kill.

    The researchers delivered the bacteria to mice along with a small orthopedic implant, to mimic the infections that often occur at the sites of medical implants. The mice were then treated with the antibiotic levofloxacin. Before and after treatment, the cells were removed and treated with ATC, a molecule that turns on the toggle switch, but only in cells that are replicating.

    Scientists have hypothesized from previous studies that chronic infections usually consist largely of non-dividing bacteria. However, in this study, the researchers found that before antibiotic treatment, about half of the bacteria were still actively dividing.

    They also found that levofloxacin appeared to be highly and perhaps even more effective against non-dividing cells, contrary to what has been seen in cells grown in a dish. The researchers noted that the percentage of replicating cells increased after treatment, suggesting that levofloxacin did not kill all of the replicating cells.

    Another surprising finding contradicted scientists’ hypothesis that chronic persistent infections consisting of non-dividing bacteria are highly tolerant to antibiotics: They found the infections were still susceptible to antibiotics, when given at large enough doses.

    More to learn

    Collins says this study demonstrates that there is much more for scientists to learn about how antibiotics work, and suggests that engineered organisms could be useful for further investigating their effects.

    “This is going to challenge people to rethink what antibiotics are doing at an infection site,” Collins says. “I think that eventually these synthetic biology tools could also be quite useful in antibiotic development, to see whether the antibiotics are getting to the pathogens of interest, how effective they are, and what they are actually doing at the site.”

    He adds that the genetic toggle switch could be easily transferred to other types of bacteria, and could also be designed to test for other features such as how bacteria interact with immune cells at an infection site. This approach could also be used to study biofilms — sticky sheets of bacterial cells that can be very difficult to remove — and other pathogens such as fungi.

    The research was funded by the Paul G. Allen Frontiers Group, the Defense Threat Reduction Agency, and the Wyss Institute.

    5:10p
    Measuring depths, scaling heights

    Graduate student Leigh Ann Kesler is pursuing her two great interests: fusion science and rock climbing. One day she finds herself scrambling up bare rock faces to view grand vistas of mountains and valleys carved by glaciers, the next she is in the laboratory, exploring minute changes in the depth of materials being eroded by fusion forces.

    Kesler studies at MIT’s Plasma Science and Fusion Center (PSFC), and dates her interest in fusion back to an 11th-grade persuasive writing assignment. Inspired in part by her father’s interest in the potential of nuclear energy, she decided to investigate fusion. Searching for the topic at the library in her Fisher, Illinois, high school, she found just one 1970s-vintage book on the topic, but its description of a magnetic fusion device called a tokamak was compelling enough to hook her for good.

    As an undergrad at the University of Illinois, Kesler studied nuclear, plasma, and radiological engineering, learning the basics about how plasmas affect materials from one of her mentors, Professor David Ruzic. Working in his laboratory on projects related to semiconductor manufacturing as well as fusion, she gained a reputation for expertise with plasma diagnostics. Graduate students several years her senior soon began to seek her help with their projects.

    “I don’t know if I was an expert,” she says, laughing. “But I had several advantages. I had small hands. I could reach inside of the bottom of the chamber [of the experiment]. I’d been there long enough that they knew I wasn’t going to break things.”

    Understanding fusion devices

    Now at MIT, she is continuing her research in materials science and fusion research under the guidance of Professor Dennis Whyte, head of the Nuclear Science and Engineering Department and director of the PSFC, and Assistant Professor Zach Hartwig. As she did in Illinois, she works in a lab that utilizes small-scale plasma devices for ex situ observation of plasma surface interactions.  

    Her main focus is erosion of materials inside fusion devices, where strong magnetic fields keep the hot plasma fuel confined and away from the walls of the vacuum chamber where fusion reactions occur. But the plasma can still affect the walls, resulting in surface erosion and other changes.

    “It’s very difficult to determine exactly how a particular kind of plasma discharge affects the interior material of the machine,” Kesler says. "We can’t be sure of the amount of erosion occurring at any particular moment. Erosion affects not only the wall materials, but also the plasma itself, which can become contaminated by the eroded materials. If you are eroding or even melting the surfaces you will eventually destroy the divertor, which is designed to remove impurities from the plasma.”

    She works mainly on a 2 megavolt electrostatic accelerator called DANTE in the Vault Laboratory for Nuclear Science, which is part of the Center for Science and Technology with Accelerators and Radiation (CSTAR). The lab is a shielded, underground facility that allows her to work safely with a deuterium ion beam. She also uses CSTAR's Cambridge Laboratory for Accelerator Surface Science, giving her the versatility of working with two ion sources.

    Kesler is searching for a way to measure, on a shot-by-shot basis, what changes are happening on the interior surface of the tokamak in order to gain a better understanding of how different plasma conditions affect surfaces. To this end, she will use the accelerator to create “depth markers” to help measure changes in the metallic surfaces. She is working with tungsten, a metal that will likely be used for the divertors of future tokamaks.

    “Accelerators can be used to implant stuff into the surface of a material," she says. A layer of a material, like boron, put close to the surface can be used as a reference point.

    "If the location of this layer changes after interacting with the plasma that means the amount of tungsten on the surface has changed," she says. "Either something has been added or something has been taken away.”

    Kesler is still fine-tuning what that reference point will be, the best material to use, how to create the depth marker, and how to use the accelerators to see how the plasma has affected the surface. Her technique should be applicable to any material and will be relevant to tokamaks around the world, allowing researchers to diagnose the effect of each plasma shot as it happens.

    “Addicted to hiking”

    While the lab keeps her busy, Kesler has been able to indulge her love of hiking and rock climbing, not only in the mountains of New England, but in places as far away as Machu Picchu, the Faroe Islands, and Mount Vesuvius. She started rock climbing during a summer internship in Los Alamos, New Mexico, where after work she would explore the area crags with friends.

    “It turned into the best summer of my life, and I was addicted to hiking and climbing after that.”

    At MIT she got involved with more aspects of the sport when she started going on trips with the MIT Outing Club (MITOC). Soon she was a hiking and climbing leader, and is currently on the board of directors.

    “MITOC has been an amazing part of my grad school experience, allowing me to make friends with shared interests and to let me escape the confines of the city on the weekends. As a country girl, I get sick of the city, so New Hampshire has been my second home while I'm here.”

    On a mountain she can study the surface of a rock that will provide her next foothold instead of the interior surface of a tokamak. She can breathe the thin air of high altitudes before returning to her underground laboratory. She was excited about her recent hike with five friends from MITOC to Gannett Peak, Wyoming’s highest point, where she was able to watch the total eclipse on Aug. 21.

    “We hiked for two days to high camp, took one day to summit, then one day to retreat. I had bruised my heel six weeks earlier in a climbing accident, so I was out of shape, but the trip was still amazing. Viewing the totality of the eclipse was mind-blowing. The 360-degree sunset/sunrise and the reality of the sun disappearing from view was something I cannot describe. It is an experience of a lifetime.”

    Now at the beginning of her sixth year, Kesler is still researching and writing, but starting to consider her options after graduation. “An international postdoctoral position in materials development would be great. But I’m not so much interested in where I go as in doing interesting work,” she says.

    Ideally that work will be situated not far from a mountain, she says. “There are always more rocks to climb.”

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