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Wednesday, April 29th, 2020

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    12:00a
    How growth of the scientific enterprise influenced a century of quantum physics

    Austrian quantum theorist Erwin Schrödinger first used the term “entanglement,” in 1935, to describe the mind-bending phenomenon in which the actions of two distant particles are bound up with each other. Entanglement was the kind of thing that could keep Schrödinger awake at night; like his friend Albert Einstein, he thought it cast doubt on quantum mechanics as a viable description of the world. How could it be real?  

    And yet, evidence keeps accumulating that entanglement exists. Two years ago MIT Professor David Kaiser and an international team used lasers, single-photon detectors, atomic clocks, and huge telescopes collecting light that had been released by distant quasars 8 billion years ago to further refine tests of quantum entanglement. The researchers thus effectively ruled out a potential objection, that the appearance of entanglement might derive from some correlation between the selection of measurements to perform and the behavior of the particles being tested.

    Yes, entanglement defies our intuition, but at least scientists can keep learning about it, Kaiser notes.

    “Schrödinger could only stay up all night,” says Kaiser, meaning that theorists in the 1930s just had “pencil and paper and very hard-thought calculations and compelling analogies” to guide them, but little physical evidence. Today, by contrast, “we have instruments to study these questions in ways that weren’t even possible experimentally or empirically until recently.”

    Now Kaiser, a professor of physics at MIT and the Germeshausen Professor of the History of Science in MIT’s Program in Science, Technology, and Society, has written a new history of the subject, “Quantum Legacies: Dispatches from an Uncertain World,” published this month by the University of Chicago Press. Moving between vignettes of key physicists, original research about the growth of the field, and accounts of his own work in cosmology, Kaiser emphasizes the vast changes in the field over time.

    “There have been really quite dramatic shifts in the fortunes of the discipline,” says Kaiser, who says he aimed to present readers with “a different kind of story, with different through-lines, over a very turbulent century.”

    The physics boom and the crash

    Indeed, many histories of quantum physics have been telescopic in form, focusing on the field’s most well-known stars: the foundational quantum theorists Niels Bohr, Paul Dirac, Werner Heisenberg, and Schrödinger, with Einstein usually featured as a famous quantum skeptic. Before the physics community was thrown into turmoil by world war, these scientists developed quantum mechanics and identified its most baffling features — including entanglement and the uncertainty principle (the trade-off in accuracy when measuring things like the position and momentum of a particle).

    We still struggle to interpret these concepts, but much else has changed. In particular, Kaiser emphasizes, physics witnessed a quarter-century of unprecedented growth starting in the 1940s, especially when students flooded back into America’s universities after World War II.

    “We trained more people in physics in that quarter-century after the war than had previously been trained, cumulatively, since the dawn of time,” Kaiser says of this growth phase.

    Meanwhile, massive particle colliders changed the methods of physics and yielded new knowledge about subatomic structures. Huge teams collaborated on experiments, strictly intent on grinding out empirical advances. More people than ever were becoming physicists, but seemingly fewer than ever pondered the “philosophical” problems raised by quantum physics, which became unfashionable.

    “It was more than a pendulum swing,” Kaiser says. “Physics saw these quite dramatic shifts in what even counted as a real question.”

    Kaiser carefully documents this shift through close readings of physics textbooks, showing how an ethos of pragmatic calculation became dominant. Textbook authors, he adds, are “always making a range of value judgements: What’s an appropriate topic, what’s an appropriate method? What should we be asking questions about? What is ‘merely’ philosophical?”

    And then the physics bubble burst: Funding, enrollment numbers, and jobs in the field all dropped precipitously in the early 1970s, due to a slowing economy and decreased federal funding.  

    “Those numbers crashed for virtually every field of study across the academy, but none fell faster than physics,” Kaiser says.

    The Tao of large colliders

    Perhaps surprisingly, that 1970s job-market crunch helped revive interest in the quantum curiosities of the 1930s. As Kaiser detailed in his 2011 book “How the Hippies Saved Physics” — which grew out of this book project — some key advances toward understanding entanglement came from then-marginal physicists who, lacking fast-track research opportunities, had relative freedom to explore neglected issues. 

    Such unconventional thinking soon began to influence teaching as well, Kaiser notes in “Quantum Legacies.” Fritjof Capra’s period bestseller “The Tao of Physics,” linking Eastern religion and quantum mysteries, is known today as a New Age staple — but it landed on academic syllabi in the 1970s, thanks to physics professors eager to lure students back to their classrooms.

    Since the 1970s, quantum physics has seen multiple mini-eras zip by. Defense spending spurred a 1980s recovery in physics, but when U.S. Congress killed the Superconducting Supercollider project in 1993, physicists in some branches of the discipline could not generate many new experimental results — until the Large Hadron Collider came online in 2008. Multiple recent academic generations have thus experienced physics as a turbulent discipline, with its fortunes tied to distant politics.

    “Sometimes people got caught out of sync, they entered physics during boom times and, through no fault of their own, the opportunities vanished before they got their degrees,” Kaiser says. “And we’ve seen that happen twice in this country in the last half-century.”

    So while the likes of Schrödinger could make progress with a pencil and paper, the material conditions of physics matter immensely as far as contemporary progress in the discipline goes.

    “The ideas matter a great deal,” Kaiser says. “But the ideas are embedded in a changing world.”

    “Quantum Legacies” has drawn praise from scholars; Nobel-winning physicist Kip Thorne of Caltech praises the book’s “remarkable set of vignettes about major developments in physics and cosmology of the past century,” which “beautifully integrate science with human history.” Award-winning novelist Nell Freudenberger notes Kaiser’s “talent for uncovering connections between otherworldly ideas and the social and political worlds in which they take shape,” which, she continues, makes for “a simply spellbinding guide to the mysteries of the universe."

    For his part, Kaiser hopes readers will ponder the “doubleness” of scientists — they hope to find eternal answers, despite being bound by their era’s tools and assumptions. And while “Quantum Legacies” explores the lives of some individual physicists, such as Dirac, Kaiser also hopes readers will appreciate how thoroughly quantum physics has been a collaborative enterprise.

    “In science there is a tradition of writing about the single genius, but quantum mechanics from day one has required an ensemble cast,” Kaiser says, adding, “When we study institutions, generations, and cohorts, I find that more valuable than thinking about these unattainable geniuses on the mountaintop — which is always a fable, but it’s an especially poor-fitting fable for this set of developments.”

    Consider, he says, that more than 15,000 physicists published papers relating to the Higgs Boson — exploring how subatomic particles acquire mass — over a 50-year span. But only after the Large Hadron Collider started running could scientists find evidence for it.

    “It makes me think about my own [work] in a different way,” Kaiser says. “What have I not been able to think of, that the next generation will open up? I find that much more exciting, as a human story, as a conceptual story, than focusing on a single lone genius.”

    4:45p
    3 Questions: Michael Yaffe on treating Covid-19 patients with acute respiratory distress

    During the Covid-19 pandemic, frontline health care workers have had to adapt rapidly to treating patients with lung failure, not only because of shortages of equipment such as ventilators often used to treat severe cases, but also because such approaches are not always effective due to the unique and still imperfectly understood pathology of Covid-19 infections.

    Michael Yaffe, the David H. Koch Professor in Science, normally divides his time among his roles as a researcher and professor of biology and biological engineering at MIT, an intensivist/trauma surgeon at Beth Israel Deaconess Medical Center (BIDMC), and a colonel in the U.S. Army Reserve Medical Corps. Currently, he is developing treatments for Covid-19 infections in his laboratory at the Koch Institute for Integrative Cancer Research at MIT. Additionally, he runs one of the Covid-19 Intensive Care Units at BIDMC and serves as co-director of the acute care and ICU section of Boston Hope, the 500-bed pop-up hospital organized by the City of Boston, Massachusetts in the Boston Convention and Exposition Center. Yaffe shares how he is working to improve outcomes for Covid-19 patients and offers his perspective on how emergency care for acute respiratory distress will need to evolve during this crisis and beyond.

    Q: What are the special considerations for Covid-19 patients receiving treatment for respiratory failure?

    A: We have known about acute respiratory distress syndrome (ARDS) for decades. It was first recognized in battlefield casualties during the Vietnam War, and was initially called “Da-Nang Lung,” but later was understood to be the result of many different diseases. In ARDS, fluid builds up in the tiny air sacs, or alveoli, preventing the lungs from filling up with enough air, and in severe cases is treated by putting patients on ventilators or other devices that support breathing.

    The type of lung injury we are seeing in Covid-19 patients behaves very differently from the traditional type of ARDS, and seems to involve early damage to the cells that line the lungs, followed by intense inflammation. The inflammation leads to a massive increase in blood clotting that affects all of the blood vessels in the body, but particularly the blood vessels in the lungs. As a consequence, even if we can force air into the lungs, it does not get delivered very efficiently into the bloodstream.

    In ICUs in Boston, New York, and Colorado, we have started a clinical trial using a clot-busting drug called tPA that we think will help rescue patients whose lungs are failing despite maximal support with a mechanical ventilator. This approach has gathered a lot of attention from other hospitals, both nationally and internationally, who are also trying this approach. The work has now led to FDA approval for this drug as an Investigational New Drug, meaning that it is now approved for use in Covid-19 ARDS in the setting of clinical trials.

    Q: How has your wide-ranging expertise equipped you to address new challenges that you face in the ICU?

    A: I have been very fortunate to be well-prepared to help out in this crisis. First, my training as an intensive care physician and trauma surgeon makes me comfortable in a crisis situation. The clinical problems that we are dealing with here  — ARDS, kidney failure, etc. — are exactly within the scope of my regular clinical practice. Second, my Army deployment experience as a surgeon and critical care doctor in Afghanistan and in Central America has made me very comfortable having to make decisions in resource-limited situations. Finally, it has been incredibly fortuitous that much of my lab's work has been in the area of cell injury, particularly cancer treatment-related cell injury, but also in the setting of a condition called systemic inflammatory response syndrome, which is essentially exactly what Covid-19 is. In this area, my lab has been studying the link between inflammation and blood clotting for over a decade, and the basic science insights from that work have now become central to our understanding of Covid-19 lung failure, which no one could have foreseen when we first started that research.

    Q: What implications do you think the Covid-19 pandemic will have for emergency care after it is over?

    A: I think the implications of Covid-19 for the future are immense. First, I hope the lessons learned from this pandemic lead to a complete re-thinking of our national public health policy (or lack of one, really) and a re-engagement with World Health Organization officials for monitoring the outbreak of emerging diseases.

    Second, I think that this crisis may fuel additional research funding in the area of critical care medicine. Before the Covid-19 crisis, very few people had heard of ARDS, or even critical care as a field of medicine, since it does not have the glamour of conditions like cancer medicine or cardiovascular disease. Historically, research in this area has been underfunded, but now that ARDS has taken the spotlight in the news, I am hopeful that the recognition that some patients with Covid-19 are dying because of critical illness and lung failure will lead to new efforts to better understand the link between inflammation, lung function, and innate immunity, including blood coagulation. The Covid-19 crisis will not end when this first wave subsides, but will re-visit us again in the fall. Additionally, other coronavirus diseases as well as viral epidemics are likely to continue to plague us in the future.

    One final lesson we are learning from this terrible pandemic is how important it is to treat all of the different parts of the body as a complex interacting unit, and to apply what we know from systems biology and other fields of study to understand how those parts are integrated into one coherent system. The lung failure, kidney failure, and inflammation of the heart that are the hallmarks of Covid-19 critical illness directly reflect how different inflammatory molecules in the blood alter the function of each of these different organ systems. Our traditional medical approach of having separate specialists in infectious disease, pulmonary medicine, renal medicine, and hematology does not work well when all the organ systems are cross-talking to each other. The job of the intensive care physician is to integrate all of the relevant basic biology and pathology of these organs into a comprehensive holistic treatment approach for the patient. Covid-19 has made that need to think across multiple disciplines and connect basic science to clinical care even more apparent.

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