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Пишет bioRxiv Subject Collection: Neuroscience ([info]syn_bx_neuro)
@ 2025-02-13 15:31:00


Previous Entry  Add to memories!  Tell a Friend!  Next Entry
Fast-timescale hippocampal processes bridge between slowly unfurling neocortical states during memory search
Prior behavioral work showed that event structure plays a key role in our ability to mentally search through memories of continuous naturalistic experience. We hypothesized that, neurally, this memory search process involves a division of labor between slowly unfurling neocortical states representing event knowledge and fast hippocampal-neocortical communication that supports retrieval of new information at transitions between events. To test this, we tracked slow neural state-patterns in a sample of ten patients undergoing intracranial electroencephalography as they viewed a movie and then searched their memories in a structured naturalistic interview. As patients answered questions ("after X, when does Y happen next?"), state-patterns from movie-viewing were reinstated in neocortex; during memory-search, states unfurled in a forward direction. Moments of state-transition were marked by low-frequency power decreases in cortex and preceded by power decreases in hippocampus that correlated with reinstatement. Connectivity-analysis revealed information-flow from hippocampus to cortex underpinning state-transitions. Together, these results support our hypothesis that fast hippocampal processes bridge between slow neocortical states during memory search.


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