Cell lipotypes localization in brain by mass spectrometry imaging
The study investigates brain lipid super-specialization by defining characteristic spectral lipotypic profiles for the five primary cerebral cell-types. Utilizing a computational approach, the research visualizes the anatomical distribution of these profiles in high spatial resolution brain tissues. This method unveils cellular stereotypic lipidic signatures within the CNS, providing a new framework for exploring the physiological roles of lipids in diverse cell types present in brain or in any other tissue.