Войти в систему

Home
    - Создать дневник
    - Написать в дневник
       - Подробный режим

LJ.Rossia.org
    - Новости сайта
    - Общие настройки
    - Sitemap
    - Оплата
    - ljr-fif

Редактировать...
    - Настройки
    - Список друзей
    - Дневник
    - Картинки
    - Пароль
    - Вид дневника

Сообщества

Настроить S2

Помощь
    - Забыли пароль?
    - FAQ
    - Тех. поддержка



Пишет bioRxiv Subject Collection: Neuroscience ([info]syn_bx_neuro)
@ 2025-08-15 12:31:00


Previous Entry  Add to memories!  Tell a Friend!  Next Entry
Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly
How do a limited number of wiring molecules specify trillions of connections in developing brains? We previously found that inverse expression of a ligand-receptor pair, Teneurin-3 (Ten3) and Latrophilin-2 (Lphn2) in CA1 and subiculum instructs CA1[->]subiculum target selection through Ten3-Ten3 homophilic attraction and Ten3-Lphn2 heterophilic reciprocal repulsion. Here, we leveraged conditional knockouts to systematically demonstrate that these mechanisms generalize to extended hippocampal connections, including entorhinal cortex and hypothalamus. Cooperation between attraction and repulsion differs depending on the order developing axons encounter the attractant and repellent subfields. Strikingly, Ten3 and Lphn2 can serve both as ligands for incoming axons and receptors for their own target selection, within the same neuron; Ten3 can be repulsive or attractive as ligand or receptor. Thus, multifunctionality and repeated use, together with the recurrent circuit motifs prevalent in the brain, enable one ligand-receptor pair to instruct target selection of many more neurons.


(Читать комментарии) (Добавить комментарий)