Crebinostat Facilitates Memory Formation
Protein modifications importantly contribute to memory formation. Protein acetylation is a posttranslational modification of proteins that regulates memory formation. Acetylation level is determined by the relative activities of acetylases and deacetylases. Crebinostat is a histone deacetylase inhibitor. Here we show that in object recognition task, Crebinostat facilitates memory formation by a weak training. Further, this compound enhances acetylation of -tubulin, and reduces the level of histone deacetylase 6, an -tubulin deacetylase. The results suggest that enhanced acetylation of -tubulin by Crebinostat contributes to its facilitatory effect on memory formation.