A new species of Ophiorriza (Rubiaceae) from southern Western Ghats, India is here described and illustrated. Ophiorriza meenachilarensis is similar to O. eriantha, from which it differs in its herbaceous habit (vs. shrubby habit), densely villous-hirsute stem (vs. pubescent-glabrous stem), entire stipule (vs. bifid stipule), short-peduncled cymes (vs. comparatively long-peduncled cymes), unscented flowers (vs. scented flowers) and corolla tube with a ring of hairs at the middle of the tube (vs. corolla tube without a ring of hairs). A detailed description, illustrations, ecological observations, and geographic distribution are provided.

 Keywords: Ophiorrhizeae, Camptothecin, Kerala, Rubioideae, Vagamon hills