Field expeditions to the Cordillera Occidental of the Colombian Andes have resulted in the discovery of a new species of Trichodrymonia (Gesneriaceae). Trichodrymonia glutinosa J.L.Clark & Clavijo is described from the western Andean slopes of the Cordillera Occidental, along the old highway between Cali and Buenaventura. The new species is a lithophytic stout herb with elongate pendent leaves and with vegetative and reproductive structures covered with a glutinous indumentum. Based on IUCN guidelines, a preliminary conservation assessment of ‘Vulnerable' (VU) is recommended for T. glutinosa.