Re: myristicin&mmda
« Reply #1 on: Yesterday at 08:25:55 PM »
Yep. There was talk of forming iodo-safrole back at the hive. Iodine is a much better leaving group than bromine, so primary amines like MDA or, in this case, MMDA are much more easily formed. The idea is to isolate myristicin. There was discussion on another forum that a good fraction of parsley seed oil had myristicin from a source but that the oil did not entirely freeze at the same points. The GC/MS that the company supplied said it had a decent fraction of myristicin. What some don't know is that many parsley seed oils also contain apiol and that the company in question may not have been proficient enough with their equipment to tell the difference between myristicin and apiol. Anyway, keep in mind that apiol might be a fraction you don't want and I think the boiling points are pretty similar.
I didn't read the Rhodium link but iodomyristicin would be an excellent way to go. There is a bee named Jon who really nailed down some interesting information on this via a different route. He isolates the terminal alkene and formed bromosafrole in situ by reacting NaBr with H2SO4. He then isolated the bromosafrole and made iodosafrole via the Finkelstein reaction with NaI in acetone. After that MDA was made easily with NH3. Go search that bee's notes on bromo and iodo-safrole and MDA at wetdreams. Some of the best notes on the subject to date can be found by reading his notes and that is probably the best way to get what you want, that is, unless you have access to NaBH3CN and want to make the corresponding ketone. Either way, you are on the right track.
Moriarty
20 most recent
Tue, Mar. 16th, 2010, 07:10 pm
myristicin2iodo-myristicin2mmda, bromo-to-iodoSafrole2mda..
Mon, Mar. 15th, 2010, 10:57 am
links
http://www.posterburner.com/ custom posters
http://www.smartpowders.com/ nootropics
http://poppyspods.com/ poppy & n. nucifera pods
http://forums.mycotopia.net/botanicals-c
http://www.africanshaman.com/
http://www.smartpowders.com/ nootropics
http://poppyspods.com/ poppy & n. nucifera pods
http://forums.mycotopia.net/botanicals-c
http://www.africanshaman.com/
Sun, Mar. 14th, 2010, 02:14 am
daily finds
http://www.lycaeum.org/rhodium/chemistry/i
http://www.pneudart.com/ :)
http://www.youtube.com/watch?v=Vf97Fn11_
http://en.wikibooks.org/wiki/Cryptograph
http://www.pneudart.com/ :)
http://www.youtube.com/watch?v=Vf97Fn11_
http://en.wikibooks.org/wiki/Cryptograph
Fri, Mar. 12th, 2010, 09:33 am
melatonin to 5MeoDMT
http://www.zoklet.net/bbs/showthread.php?p=1
dude fucks up at the end - sep funnel spill (and i thought only i was that lame), but still yields enough product.
dude fucks up at the end - sep funnel spill (and i thought only i was that lame), but still yields enough product.
Fri, Mar. 12th, 2010, 02:52 am
daily info mining
http://lifehacker.com/
tips and downloads for getting things done
http://www.textbookrevolution.org/index.p
http://zshare.net/
http://www.securityfocus.com/
http://www.globalsecurity.org/military/l
http://www.lycaeum.org/rhodium/chemistry/i
http://www.tuxradar.com/content/newbies-g
http://forum.rorta.net/
http://t-militia.org/
http://www.zoklet.net/
http://www.textbookrevolution.org/index.p
http://zshare.net/
http://www.securityfocus.com/
http://www.globalsecurity.org/military/l
http://www.lycaeum.org/rhodium/chemistry/i
http://www.tuxradar.com/content/newbies-g
http://forum.rorta.net/
http://t-militia.org/
http://www.zoklet.net/
Fri, Mar. 12th, 2010, 02:50 am
mmda synth from parsley/nutmeg oil (myristicin)
Thu, Mar. 11th, 2010, 02:03 am
google webbits collection
+inurl:mp3 site:sharebee.com velvet underground
+inurl:pdf|doc|lit site:sharebee.com
-inurl:htm -inurl:html intitle:”index of” +(“/ebooks”|”/book”) +(chm|pdf|zip) +”For Dummies”
or
-inurl:htm -inurl:html intitle:"index of" +("/ebooks"|"/book") +(chm|pdf|zip) +"o'reilly"
"http://*:*@www" site passwords for site, stored as the string "http://username: password@www..."
filetype:xls inurl:"email.xls" email.xls files, potentially containing contact information
"not for distribution" confidential documents containing the confidential clause
reports for network security scans, penetration tests etc.
"Network Vulnerability Assessment Report"
"Host Vulnerability Summary Report"
filetype:pdf "Assessment Report"
"This file was generated by Nessus"
Queries for locating network devices
inurl:"printer/main.html" intext:"settings" Brother HL printers
inurl:hp/device/this.LCDispatcher HP printers
intitle:index.of finances.xls finances.xls files, potentially containing information on bank ac-
counts, financial summaries and credit card numbers
filetype:ctt "msn" MSN contacts list
buddylist.blt AIM contacts list
http://www.hackersforcharity.org/ghdb/ google hacking database
+inurl:pdf|doc|lit site:sharebee.com
-inurl:htm -inurl:html intitle:”index of” +(“/ebooks”|”/book”) +(chm|pdf|zip) +”For Dummies”
or
-inurl:htm -inurl:html intitle:"index of" +("/ebooks"|"/book") +(chm|pdf|zip) +"o'reilly"
"http://*:*@www" site passwords for site, stored as the string "http://username: password@www..."
filetype:xls inurl:"email.xls" email.xls files, potentially containing contact information
"not for distribution" confidential documents containing the confidential clause
reports for network security scans, penetration tests etc.
"Network Vulnerability Assessment Report"
"Host Vulnerability Summary Report"
filetype:pdf "Assessment Report"
"This file was generated by Nessus"
Queries for locating network devices
inurl:"printer/main.html" intext:"settings" Brother HL printers
inurl:hp/device/this.LCDispatcher HP printers
intitle:index.of finances.xls finances.xls files, potentially containing information on bank ac-
counts, financial summaries and credit card numbers
filetype:ctt "msn" MSN contacts list
buddylist.blt AIM contacts list
http://www.hackersforcharity.org/ghdb/ google hacking database
Wed, Mar. 10th, 2010, 10:57 pm
feistel networks, XOR. block cipher basics.
Feistel Networks --- A Feistel network is a general method of transforming any function (usually called the F function) into a permutation. It was invented by Horst Feistel [FNS75] in his design of Lucifer [Fei73], and popularized by DES [NBS77].
All commonly used symmetric block ciphers are product ciphers; they are strong ciphers constructed by many iterations of a round function, which is itself a kind of weak cipher. In a Feistel cipher, the round function consists of taking one part of the data being encrypted, feeding it into some key dependent function F, and then XORing (or otherwise combining) the result into another part of the block. If the part of the data used as input to the F function and the part of the data combined with output from the F function are each half of the block, then the cipher is a “balanced” Feistel network [SK96].
XOR - The logical operation exclusive disjunction, also called exclusive or (symbolized XOR, EOR, or ⊕), is a type of logical disjunction on two operands that results in a value of true if exactly one of the operands has a value of true.[1] A simple way to state this is "one or the other but not both."
XOR truth table
F, F -- F 0, 0 -- 0
F, T -- T or 0, 1 -- 1
T, F -- T 1, 0 -- 1
T, T -- F 1, 1 -- 1
symbol: ><
Whitening: The technique of XORing key material before the first round and after the last round, was used by Ralph Merkle in Khufu/Khafre, and independently invented by Ron Rivest for DES-X [KR96a].
S-boxes -- An S-box is a table-driven non-linear substitution operation used in most block ciphers. S-boxes vary in both input size and output size, and can be created either randomly or algorithmically. S-boxes were first used in Lucifer, then DES, and afterwards in most encryption algorithms.
(from "Wiley - Bruce Schneier - The Twofish Encryption Algorithm - A 128--Bit Block Cipher")
All commonly used symmetric block ciphers are product ciphers; they are strong ciphers constructed by many iterations of a round function, which is itself a kind of weak cipher. In a Feistel cipher, the round function consists of taking one part of the data being encrypted, feeding it into some key dependent function F, and then XORing (or otherwise combining) the result into another part of the block. If the part of the data used as input to the F function and the part of the data combined with output from the F function are each half of the block, then the cipher is a “balanced” Feistel network [SK96].
XOR - The logical operation exclusive disjunction, also called exclusive or (symbolized XOR, EOR, or ⊕), is a type of logical disjunction on two operands that results in a value of true if exactly one of the operands has a value of true.[1] A simple way to state this is "one or the other but not both."
XOR truth table
F, F -- F 0, 0 -- 0
F, T -- T or 0, 1 -- 1
T, F -- T 1, 0 -- 1
T, T -- F 1, 1 -- 1
symbol: ><
Whitening: The technique of XORing key material before the first round and after the last round, was used by Ralph Merkle in Khufu/Khafre, and independently invented by Ron Rivest for DES-X [KR96a].
S-boxes -- An S-box is a table-driven non-linear substitution operation used in most block ciphers. S-boxes vary in both input size and output size, and can be created either randomly or algorithmically. S-boxes were first used in Lucifer, then DES, and afterwards in most encryption algorithms.
(from "Wiley - Bruce Schneier - The Twofish Encryption Algorithm - A 128--Bit Block Cipher")
Wed, Mar. 10th, 2010, 02:27 am
Easy, High Yield MDA
Easy, High Yield MDA
Exerpt from something I heard somewhere.......
The Finkelstein reaction is the word for the day! Bromosafrole in acetone treated with KI to form the iodide (iodine is a much better leaving group). Iodosafrole forms the amine with NH3 alone at normal pressure. Start to finish MDA in the +90%!
Or, as per twodogs:
Quote:The following reactions make use of a commercially available product that goes under various trade names eg Helional, Floramelon.
The aldoxime of this aldehyde undergoes the Beckman rearrangement with Nickel Acetate to give the amide that is then easily transformed to the amine by the Hoffman reaction. The Hoffman reaction can be achieved with 4.2% NaOCl sold in supermarkets as bleach.
I don't have any references as this was done a while ago. The aldoxime and Hoffman reactions are pretty standard. The Beckman rearrangement of this particular product using Nickel Acetate is my own work.
It doesn't get any easier that this.
The aldoxime.
100 grms of the aldehyde is placed in 200 mls of ETOH with 50-60 grms of Hydroxylamine Hydrochloride * in 100 mls of H2O. 40 grms of Sodium Carbonate in 100 mls of H2O is slowly added with stirring. Once addition is complete the mixture is stirred overnight then filtered to give about 100 grms of the aldoxime. If the aldoxime doesn't solidify add more hydroxylamine and base.
The amide.
100 grms of the aldoxime is mixed with 300 mls of xylene and 2 grms of Nickel Acetate ** is added and refluxed for 5 hours. About 100 mls of xylene is distilled off and the mixture is left to cool. About 70 grms of the amide separates and is filtered and dried,. Can be recrystallized with xylene.
The amine.
To a solution of 10 grms NaOH in 200 mls H2O in a 500 mls flask is added 20 grms of the amide and 250 grms of 4.2 % NaOCl . The mixture is then heated to 80C with stirring. At about 50 to 60C the mixture can become white as the carbonate forms. At 70 – 80C an oil separates. (This is crude MDA). The solution was cooled and extracted with xylene. The solution was filtered and the filtrate washed with xylene and the xylene portions added together. About 100 mls of conc HCL was added to the xylene shaken and separated. The aqueous solution was extracted with xylene and the xylene separated. The amine was then liberated from the aqueous portion with NaOH and worked up in the usual way to give MDA
* Hydroxylamine HCL
200 mls nitromethane, 300 mls Acetic acid and 300 mls HCL are heated to just below reflux and held there for 2 hours then refluxed for 12 hours. The solution is reduced to half gone the cooled in fridge overnight and filtered.
**Nickel Acetate
20 grms of nickel oxide (black) is dissolved in Acetic acid and heated with stirring until the mixture turns pale green. The excess Acetic is drained off , the rest is dried and powdered.
Making Hydroxylamine HCl
http://psychonaut.com/post-35899.html?f=4
Exerpt from something I heard somewhere.......
The Finkelstein reaction is the word for the day! Bromosafrole in acetone treated with KI to form the iodide (iodine is a much better leaving group). Iodosafrole forms the amine with NH3 alone at normal pressure. Start to finish MDA in the +90%!
Or, as per twodogs:
Quote:The following reactions make use of a commercially available product that goes under various trade names eg Helional, Floramelon.
The aldoxime of this aldehyde undergoes the Beckman rearrangement with Nickel Acetate to give the amide that is then easily transformed to the amine by the Hoffman reaction. The Hoffman reaction can be achieved with 4.2% NaOCl sold in supermarkets as bleach.
I don't have any references as this was done a while ago. The aldoxime and Hoffman reactions are pretty standard. The Beckman rearrangement of this particular product using Nickel Acetate is my own work.
It doesn't get any easier that this.
The aldoxime.
100 grms of the aldehyde is placed in 200 mls of ETOH with 50-60 grms of Hydroxylamine Hydrochloride * in 100 mls of H2O. 40 grms of Sodium Carbonate in 100 mls of H2O is slowly added with stirring. Once addition is complete the mixture is stirred overnight then filtered to give about 100 grms of the aldoxime. If the aldoxime doesn't solidify add more hydroxylamine and base.
The amide.
100 grms of the aldoxime is mixed with 300 mls of xylene and 2 grms of Nickel Acetate ** is added and refluxed for 5 hours. About 100 mls of xylene is distilled off and the mixture is left to cool. About 70 grms of the amide separates and is filtered and dried,. Can be recrystallized with xylene.
The amine.
To a solution of 10 grms NaOH in 200 mls H2O in a 500 mls flask is added 20 grms of the amide and 250 grms of 4.2 % NaOCl . The mixture is then heated to 80C with stirring. At about 50 to 60C the mixture can become white as the carbonate forms. At 70 – 80C an oil separates. (This is crude MDA). The solution was cooled and extracted with xylene. The solution was filtered and the filtrate washed with xylene and the xylene portions added together. About 100 mls of conc HCL was added to the xylene shaken and separated. The aqueous solution was extracted with xylene and the xylene separated. The amine was then liberated from the aqueous portion with NaOH and worked up in the usual way to give MDA
* Hydroxylamine HCL
200 mls nitromethane, 300 mls Acetic acid and 300 mls HCL are heated to just below reflux and held there for 2 hours then refluxed for 12 hours. The solution is reduced to half gone the cooled in fridge overnight and filtered.
**Nickel Acetate
20 grms of nickel oxide (black) is dissolved in Acetic acid and heated with stirring until the mixture turns pale green. The excess Acetic is drained off , the rest is dried and powdered.
Making Hydroxylamine HCl
http://psychonaut.com/post-35899.html?f=4
Tue, Mar. 9th, 2010, 04:47 pm
more links
Tue, Mar. 9th, 2010, 12:20 pm
Loperamide & the BBB
Loperamide -> 4 Day Smack
« on: January 10, 2010, 08:57:23 PM »
Thanks to beebo from the Hive & Wetdreams...
Loperamide is an opioid anti diarrheal, structurally similar to methadone, but not usually a compound that is psychoactive.
From wiki: "Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus large intestines; by itself it does not affect the central nervous system like other opioids."
Well, let's change that, shall we?
First off, beebo discovered that mannitol has been used for some time to shrink the endothelial cells of the blood brain barrier to let things in to the brain which might seem like a bad idea... Exposing the brain to the unfiltered blood soup & all. Well, it's been done for decades now with cocaine as the typical cutting agent & they use this also for priming heart/lung machines during bypass so one might surmise that there's something else keeping the brain protected. As of this post, I'm unclear what that system is. Perhaps things still need a proper transport mechanism? If you have any information about that issue, please post.
Now that we've used mannitol about 2 hrs before hand to prime the BBB for passage, we need a proper transport mechanism for the loperamide. Polysorbate 80 is that mechanism. Thank you again, beebo. Mixing PS80 & loperamide under dry conditions causes nanoparticles to form. Basically, the PS80 encapsulates the loperamide. The brain sees the PS80 as usable fuel. These are taken up, enzymatically cleaved, exposing the loperamide & the lope binds to u-opioid receptors in the brain instead of the gut. IV administration is choice for this however it's told to be inactive orally. The potency is said to be near on par with morphine, the reported feel is much like demerol with an activity period often lasting 3 - 4 days.
The product can be easily acylated to yield a drug closer to heroin in potency with the same duration.
Now, it's up to you to learn how to extract your loperamide & find PS80 that isn't mixed with PEG & source your mannitol.
Enjoy.
Credit due to beebo (that insane fucking moose) for breaking the paradigm open & to jon for the detailed research into SAR studies, efficacy tweaking & acylation to stronger analogs.
« on: January 10, 2010, 08:57:23 PM »
Thanks to beebo from the Hive & Wetdreams...
Loperamide is an opioid anti diarrheal, structurally similar to methadone, but not usually a compound that is psychoactive.
From wiki: "Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus large intestines; by itself it does not affect the central nervous system like other opioids."
Well, let's change that, shall we?
First off, beebo discovered that mannitol has been used for some time to shrink the endothelial cells of the blood brain barrier to let things in to the brain which might seem like a bad idea... Exposing the brain to the unfiltered blood soup & all. Well, it's been done for decades now with cocaine as the typical cutting agent & they use this also for priming heart/lung machines during bypass so one might surmise that there's something else keeping the brain protected. As of this post, I'm unclear what that system is. Perhaps things still need a proper transport mechanism? If you have any information about that issue, please post.
Now that we've used mannitol about 2 hrs before hand to prime the BBB for passage, we need a proper transport mechanism for the loperamide. Polysorbate 80 is that mechanism. Thank you again, beebo. Mixing PS80 & loperamide under dry conditions causes nanoparticles to form. Basically, the PS80 encapsulates the loperamide. The brain sees the PS80 as usable fuel. These are taken up, enzymatically cleaved, exposing the loperamide & the lope binds to u-opioid receptors in the brain instead of the gut. IV administration is choice for this however it's told to be inactive orally. The potency is said to be near on par with morphine, the reported feel is much like demerol with an activity period often lasting 3 - 4 days.
The product can be easily acylated to yield a drug closer to heroin in potency with the same duration.
Now, it's up to you to learn how to extract your loperamide & find PS80 that isn't mixed with PEG & source your mannitol.
Enjoy.
Credit due to beebo (that insane fucking moose) for breaking the paradigm open & to jon for the detailed research into SAR studies, efficacy tweaking & acylation to stronger analogs.
Tue, Mar. 9th, 2010, 11:34 am
daily finds
http://duckduckgo.com/ simple search engine with clean interface, great for certain purposes
http://www.tineye.com/ "You can submit an image to TinEye to find out where it came from, how it is being used, if modified versions of the image exist, or to find higher resolution versions. TinEye is the first image search engine on the web to use image identification technology rather than keywords, metadata or watermarks."
http://www.piracetam.net/ sourcing nootropics and smart drugs at competitive prices
http://www.lookchem.com/ sourcing chems
http://www.ec21.com/ global b2b marketplace
http://www.security-forums.com/index.php
http://skreemr.com/ great mp3 search engine
http://news.ycombinator.com/newest hackernews
http://www.tineye.com/ "You can submit an image to TinEye to find out where it came from, how it is being used, if modified versions of the image exist, or to find higher resolution versions. TinEye is the first image search engine on the web to use image identification technology rather than keywords, metadata or watermarks."
http://www.piracetam.net/ sourcing nootropics and smart drugs at competitive prices
http://www.lookchem.com/ sourcing chems
http://www.ec21.com/ global b2b marketplace
http://www.security-forums.com/index.php
http://skreemr.com/ great mp3 search engine
http://news.ycombinator.com/newest hackernews
Tue, Mar. 9th, 2010, 02:37 am
Shiitake Growers Handbook
Tue, Mar. 9th, 2010, 02:34 am
UC Berkeley Video and Podcasts for Courses and Events
Tue, Mar. 9th, 2010, 01:46 am
AdventureGame Studio
Tue, Mar. 9th, 2010, 01:40 am
absinthe
анасон - Pimpinella anisum
пелин - Artemesia absinthium
бергамот - Citrus bergamia
копър - Foeniculum vulgare
невен - Calendula officinalis
женско биле - Glycyrrhiza glabra
ангелика (пищялка)
Calamus acorus
Damiana - Turnera diffusa
Sweet worm?