Да.

То, что ниже рекомендует tristes_tigres
в принципе то, но под виндовс.
Нужен аналог под dos.

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DOSBox is capable of timing-compatible implementation of the serial ports, and can run older hardware and software dependent on such; however, some USB devices that are supported by the host OS can act as a replacement for older serial port devices when using the emulator.

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