перверсии интроверсии - схема ок

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May 27th, 2014


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01:26 am - схема ок


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From:[info]polytheme
Date:May 26th, 2014 - 11:16 pm
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вот да, весь вопрос в том, можно ли научиться программировать на этом странном языке из клубков обратных связей
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From:[info]ninjascannot
Date:May 26th, 2014 - 11:54 pm
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Ну, вообще, на сегодняшний день биология больше похожа не на программирование, а на переставление уже готовых клубочков, но в последнее время стали появлятся определенные поползновения в эту сторону: вот, например, граждане создали цепочки ДНК, содержащие синтетические нуклеотиды и теперь собираются строить на их основе белки из синтетических же аминокислот
http://libgen.org/scimag6/10.1038/nature13314.pdf
We have demonstrated that PtNTT2 efficiently imports d5SICSTP
and dNaMTPinto E. coli and that an endogenous polymerase, possibly
pol I, efficiently uses the unnatural triphosphates to replicate DNA containing
the UBP within the cellular environmentwith reasonable efficiency
and fidelity. Moreover, the UBP appears stable during both exponential
and stationary phase growth despite the presence of all DNA repair
mechanisms. Remarkably, although expression of PtNTT2 results in a
somewhat reduced growth rate, neither the unnatural triphosphates nor
replication of theUBP results in significant further reduction in growth.
The resulting bacterium is the first organism that stably harbours DNA
containing three base pairs. In the future, this organism, or a variantwith
the UBP incorporated at other episomal or chromosomal loci, should
provide a synthetic biology platform to orthogonally re-engineer cells,
with applications ranging from site-specific labelling of nucleic acids
in living cells to the construction of orthogonal transcription networks
and eventually the production and evolution of proteins with multiple,
different unnatural amino acids.

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