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May 27th, 2014
Comments:
вот да, весь вопрос в том, можно ли научиться программировать на этом странном языке из клубков обратных связей
Ну, вообще, на сегодняшний день биология больше похожа не на программирование, а на переставление уже готовых клубочков, но в последнее время стали появлятся определенные поползновения в эту сторону: вот, например, граждане создали цепочки ДНК, содержащие синтетические нуклеотиды и теперь собираются строить на их основе белки из синтетических же аминокислот http://libgen.org/scimag6/10.1038/nature13314.pdfWe have demonstrated that PtNTT2 efficiently imports d5SICSTP and dNaMTPinto E. coli and that an endogenous polymerase, possibly pol I, efficiently uses the unnatural triphosphates to replicate DNA containing the UBP within the cellular environmentwith reasonable efficiency and fidelity. Moreover, the UBP appears stable during both exponential and stationary phase growth despite the presence of all DNA repair mechanisms. Remarkably, although expression of PtNTT2 results in a somewhat reduced growth rate, neither the unnatural triphosphates nor replication of theUBP results in significant further reduction in growth. The resulting bacterium is the first organism that stably harbours DNA containing three base pairs. In the future, this organism, or a variantwith the UBP incorporated at other episomal or chromosomal loci, should provide a synthetic biology platform to orthogonally re-engineer cells, with applications ranging from site-specific labelling of nucleic acids in living cells to the construction of orthogonal transcription networks and eventually the production and evolution of proteins with multiple, different unnatural amino acids. |
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LJ.Rossia.org |