Настроение:	amused
Музыка:	Death Keep Soundtrack
Entry tags:	transitioning

You're bald, because your maternal line fucked with degenerates
mtDNA Damage Accumulates with Age

Mitochondrial DNA is highly exposed to oxidative stress (ROS) and has limited repair mechanisms.

In balding scalps:

Studies have found mtDNA deletions and mutations.

Increased 8-OHdG (a marker of mtDNA oxidative damage) in dermal papilla cells of AGA patients.

These cells become senescent, losing their ability to support hair follicles.

3. Mitochondrial Dysfunction = Increased ROS = Hair Loss

Excessive reactive oxygen species (ROS) from malfunctioning mitochondria:

Trigger apoptosis in follicle-supporting cells.

Inhibit Wnt/β-catenin signaling, which is essential for hair growth.

Push cells into a fibrotic, aging state.

In AGA, there’s a pattern of premature aging and inflammation around miniaturizing follicles.

4. Maternal Inheritance Clues

mtDNA is maternally inherited.

While baldness is polygenic (many genes, including autosomal and X-linked), some studies have found:

Correlation between maternal family history and AGA severity.

Suggests mtDNA or mitochondrial factors could contribute.

5. DHT + Mitochondrial Interaction

DHT (dihydrotestosterone) sensitivity in AGA affects dermal papilla cells.

DHT has been shown to:

Downregulate mitochondrial gene expression.

Promote mitochondrial fragmentation and cellular stress in hair follicles.

This implies that mitochondrial dysfunction may not only be a result of baldness but also a driver when combined with hormonal signals.

both microneedling and aggressive scalp massage work on the same fundamental principle: they trigger controlled micro-injury to the scalp, which initiates a regenerative wound-healing response that can reactivate dormant hair follicles.

Let’s go deeper into how and why this works — from both a mechanical and molecular standpoint:

A. Inflammatory Phase (Days 1–3)

Damage signals (DAMPs) activate immune cells.

Release of cytokines like IL-6, TNF-α, and IL-1β.

Recruitment of macrophages, which clear debris and secrete pro-regenerative factors.

B. Proliferation Phase

Wnt/β-catenin pathway gets activated — this is crucial for anagen (growth phase) re-entry.

Increased fibroblast activity, angiogenesis (new blood vessels), and collagen remodeling.

Stimulation of hair follicle stem cells (HFSCs) in the bulge area.

C. Mitochondrial and Metabolic Response

Cells in the hair follicle shift from quiescent metabolism (glycolysis) to active mitochondrial respiration (OXPHOS).

ROS generated by mitochondria act as signaling molecules, not damage, at low levels.

Boost in ATP, NAD+, and SIRT1 activity helps drive stem cell proliferation and differentiation.